LATE LIVER METASTASIS 20 YEARS AFTER THE INITIAL DIAGNOSIS: A CASE REPORT OF METACHRONOUS HORMONE DEPENDENT TUMORS OF BREAST AND ENDOMETRIUM

Breast cancer is the most common and a significant cause of morbidity mortality in female population worldwide. The liver third metastatic site for invasive breast malignancy besides bones, lungs brain. has been linked with metachronous bone, endometrial, colon/rectal, connective tissue (sarcoma), leukemia, lung, ovary or thyroid cancer. Studies have shown an increased risk secondary malignancies women treated connection to adjuvant treatment certain cases. We present case 71 year old woman who was diagnosed 20 years ago. primary diagnosis lobular localized left lower lateral quadrant. Micromorphological, histochemical immunohistochemical analyses rendered inconclusive due lack so after 4 months rebiopsy performed. Clinico-pathological correlation second biopsy favor metastasis partially hormone dependent Immunohistochemistry vital on biopsy, particular GATA3 positivity vimentin negative staining which helped us exclude endometrial before initial biopsy. GATA 3(+)/vimentin(-) panel proved be superior GCDFP-15 mammaglobin proving origin tumor deposit.Liver from can cases occur many shows importance necessity long term follow-up these patients, while considering possibility tumors as well.